MODULATION OF MEMBERS OF THE TNF-SUPERFAMILY

It has been demonstrated that certain compounds bind to TNT and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compoun...

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Bibliographische Detailangaben
Hauptverfasser:	LAWSON, Alastair, O'CONNELL, James Philip, PORTER, John Robert, MCMILLAN, David James, BROOKINGS, Daniel Christopher, KROEPLIEN, Boris, WARRELLOW, Graham John, RAPECKI, Stephen Edward, NORMAN, Timothy John, ALEXANDER, Rikki Peter
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING
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Beschreibung
Zusammenfassung:	It has been demonstrated that certain compounds bind to TNT and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.