IMPROVED PROCESSES FOR THE PREPARATION OF SOFOSBUVIR AND INTERMEDIATES THEREOF

IMPROVED PROCESSES FOR THE PREPARATION OF SOFOSBUVIR AND INTERMEDIATES THEREOF

The present disclosure provides procedures and intermediates for the preparation of Sofosbuvir, comprising the step of reacting a compound of formula 2: wherein R1 and R2 can independently be hydrogen or halogen, provided that at least one of R1 and R2 is a halogen.

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Bibliographische Detailangaben
Hauptverfasser: YAZALI, Venkata, Subbarao, GOSWAMI, Miteshgir, Kanchangir, MISTRY, Dhirenkumar, Natvarial, ACHANTA, Srinivas, KANSAL, Vinod, Kumar, ARIYAMUTHU, Sundaraselvan
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:The present disclosure provides procedures and intermediates for the preparation of Sofosbuvir, comprising the step of reacting a compound of formula 2: wherein R1 and R2 can independently be hydrogen or halogen, provided that at least one of R1 and R2 is a halogen.