METHODS FOR ESTABLISHING THRESHOLD LIMITS FOR A CHEMICAL OR BIOLOGICAL AGENT IN A TARGET SPECIES

Methods are provided for establishing a threshold exposure limit to a chemical or biological agent for the members of a target species taking into account the potential for variation in responses among the members of that species. Exemplary exposures include maximum safe exposure to a toxic agent, o...

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Bibliographische Detailangaben
Hauptverfasser: COYNE, Kevin P, COYNE, Shawn T
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Methods are provided for establishing a threshold exposure limit to a chemical or biological agent for the members of a target species taking into account the potential for variation in responses among the members of that species. Exemplary exposures include maximum safe exposure to a toxic agent, or minimum effective dose for a pharmaceutical. The method is particularly useful under circumstances wherein variation in responsiveness to the agent cannot be ascertained by directly exposing members of the target species to the agent.