METHODS FOR ESTABLISHING THRESHOLD LIMITS FOR A CHEMICAL OR BIOLOGICAL AGENT IN A TARGET SPECIES
Methods are provided for establishing a threshold exposure limit to a chemical or biological agent for the members of a target species taking into account the potential for variation in responses among the members of that species. Exemplary exposures include maximum safe exposure to a toxic agent, o...
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Zusammenfassung: | Methods are provided for establishing a threshold exposure limit to a chemical or biological agent for the members of a target species taking into account the potential for variation in responses among the members of that species. Exemplary exposures include maximum safe exposure to a toxic agent, or minimum effective dose for a pharmaceutical. The method is particularly useful under circumstances wherein variation in responsiveness to the agent cannot be ascertained by directly exposing members of the target species to the agent. |
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