BENZOIMIDAZOLE DERIVATIVES AS PAD4 INHIBITORS

BENZOIMIDAZOLE DERIVATIVES AS PAD4 INHIBITORS

Compounds of formula (I): wherein X, Y, R1 and R3-R11 are as herein defined, and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DOUAULT, Clement, LIDDLE, John, WALKER, Ann, Louise, AMANS, Dominique, WILSON, David, Matthew, ATKINSON, Stephen, John, GARTON, Neil, Stuart, RENAUX, Jessica, Fanny, BARKER, Michael, David, SHEPPARD, Robert, John, CAMPBELL, Matthew, DIALLO, Hawa, WELLAWAY, Christopher, Roland
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Compounds of formula (I): wherein X, Y, R1 and R3-R11 are as herein defined, and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.