PROCESS FOR THE PREPARATION OF EFINACONAZOLE

The present invention provides an improved process for the preparation of Efinaconazole in higher yield by the ring-opening addition reaction of epoxytriazole with 4-methylenepiperidine or its acid addition salt under mild conditions without using a large excess of 4-methylenepiperidine in the prese...

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Bibliographische Detailangaben
Hauptverfasser:	SASANE, Sachin, Arun, VYAS, Rajesh, Harishankar, BHISE, Nandu, Baban, KUMBHAR, Krishnat, Hanmant, SINGH, Girij, Pal, VARMA, Devendrakumar, Paramsukh
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The present invention provides an improved process for the preparation of Efinaconazole in higher yield by the ring-opening addition reaction of epoxytriazole with 4-methylenepiperidine or its acid addition salt under mild conditions without using a large excess of 4-methylenepiperidine in the presence of an alkali or an alkaline earth metal halide.