DEVICES AND METHODS FOR SAMPLE ANALYSIS

Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag att...

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Bibliographische Detailangaben
Hauptverfasser:	HAYDEN, Mark A, PRIETO-BALLENGEE, Edna M, LEARY, Thomas, TETIN, Sergey, RUAN, QiaoQiao, SONI, Pathik, HUFF, Jeffrey B, YARNELL, Lyle, KARABATSOS, Peter J, MURPHY, M. Shawn, MUERHOFF, Anthony S, BOGDAN, Felicia, HAACK, Richard, HOLETS-MCCORMACK, Shelley R, HOUSE, Dustin, POPE, Mark R, QIAO, Lei, FISCHER, Andrew T, HERSHBERGER, Stefan, LAURENSON, Sophie, SCHAPALS, Andrew S
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
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Beschreibung
Zusammenfassung:	Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided.