HYDROGEL PRECURSOR FORMULATION AND THE USE THEREOF

The present invention relates to a hydrogel precursor formulation which is in the form of an unreacted powder. It comprises an activating enzyme, preferably thrombin, a cross-linking enzyme, preferably a transglutaminase, more preferably factor XIII transglutaminase, wherein the cross-linking enzyme...

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Bibliographische Detailangaben
Hauptverfasser: Rizzi, Simone, Touati, Jeremy
Format: Patent
Sprache:eng ; fre ; ger
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Beschreibung
Zusammenfassung:The present invention relates to a hydrogel precursor formulation which is in the form of an unreacted powder. It comprises an activating enzyme, preferably thrombin, a cross-linking enzyme, preferably a transglutaminase, more preferably factor XIII transglutaminase, wherein the cross-linking enzyme is activatable by the activating enzyme in water with or without a buffer, and at least one structural compound A. Said structural compound is crosslinkable by a selective reaction mediated by the cross-linking enzyme to form a hydrogel, wherein the cross-linking enzyme is activated.