TOLL-LIKE RECEPTOR 4 ANTAGONISTS AND USE IN AUTOIMMUNE LIVER DISEASES

TOLL-LIKE RECEPTOR 4 ANTAGONISTS AND USE IN AUTOIMMUNE LIVER DISEASES

The present invention relates to new medical uses of morphinans such as naltrexone, nalmefene and their related derivatives. The present invention relates to Toll-like receptor 4 (TLR4) antagonist compounds, and pharmaceutical formulations thereof, and use thereof for prevention and treatment of aut...

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Bibliographische Detailangaben
Hauptverfasser: CHIU, Peter JS, HSU, Mei-chi, SHIH, Ying-Chu, WU, Edwin SC
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention relates to new medical uses of morphinans such as naltrexone, nalmefene and their related derivatives. The present invention relates to Toll-like receptor 4 (TLR4) antagonist compounds, and pharmaceutical formulations thereof, and use thereof for prevention and treatment of autoimmune liver diseases including but not limited to autoimmune hepatitis.