SOLID DISPERSION CONTAINING DUTASTERIDE, AND COMPOSITION CONTAINING SAME
The present invention relates to a pharmaceutical composition containing dutasteride and a method for preparing same. More specifically, the solubility of a drug has been increased by preparing an inclusion complex from gamma-cyclodextrin which is good for solidification so as to prepare a solid for...
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Format: | Patent |
Sprache: | eng ; fre ; ger |
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Zusammenfassung: | The present invention relates to a pharmaceutical composition containing dutasteride and a method for preparing same. More specifically, the solubility of a drug has been increased by preparing an inclusion complex from gamma-cyclodextrin which is good for solidification so as to prepare a solid formulation containing dutasteride and by preparing a solid dispersion from the inclusion complex and a thickener and/or a surfactant. The solid formulation for oral administration comprising the solid dispersion granules prepared according to the present invention is shown to be bioequivalent with an Avodart soft capsule. |
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