METHOD FOR CONTROLLING CONTINUOUS CHROMATOGRAPHY AND MULTI-COLUMN CHROMATOGRAPHY ASSEMBLY

Methods of controlling at least one multi-column chromatography arrangement for the continuous process of purifying biopharmaceuticals are provided. The methods include introducing a first multi-component mixture into a column of the multi-column chromatography arrangement; detecting at least one mu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	ROLINGER, Laura, BRESTRICH, Nina, RÜDT, Matthias, HUBBUCH, Jürgen
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS SEPARATION TESTING TRANSPORTING
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Methods of controlling at least one multi-column chromatography arrangement for the continuous process of purifying biopharmaceuticals are provided. The methods include introducing a first multi-component mixture into a column of the multi-column chromatography arrangement; detecting at least one multivariate signal by at least one detector; calculating at least one process parameter on the basis of the multivariate signal by at least one data-processing program of a computing unit via application of a chemometric method; and controlling the purification process via control of at least one controllable control element on the basis of the at least one process parameter.