PHARMACEUTICAL TABLET COMPOSITION

The object of the present invention is a pharmaceutical tablet composition comprising an NSAID and a PPI and having improved stability and bioavailability. The present invention relates to a pharmaceutical tablet composition comprising: a) a multilayer tablet core comprising: i) a non-steroidal anti...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	STANGELJ, Veronika, PAVLIN, Darja, SLANC-VOVK, Janika, VRECER, Franc, SIMONCIC, Kristina Debeljak, HUDOVORNIK, Grega, KUKEC, Simon, SKUBE, Maja Kincl
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The object of the present invention is a pharmaceutical tablet composition comprising an NSAID and a PPI and having improved stability and bioavailability. The present invention relates to a pharmaceutical tablet composition comprising: a) a multilayer tablet core comprising: i) a non-steroidal anti- inflammatory drug (NSAID) layer comprising an NSAID and at least one pharmaceutically acceptable excipient; ii) an optional middle layer; iii) a proton pump inhibitor (PPI) layer comprising multiple units of PPI coated with a protective coating; b) a barrier coating surrounding the multilayer tablet core; and c) a gastro-resistant coating surrounding the barrier coating.