METHOD FOR PRODUCING CRYSTALS OF DIAZABICYCLOOCTANE DERIVATIVE AND STABLE LYOPHILIZED PREPARATION

The objects of the present invention are to provide a process for producing crystals of compound (I) easily in an industrial scale, and a stable lyophilized composition of compound (I). It has been found that subjecting an aqueous solution containing compound (I) and an inorganic salt such as sodium...

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Bibliographische Detailangaben
Hauptverfasser:	ICHIKI, Masato, YOKOYAMA, Takuya, FUSHIHARA, Kenichi, FURUYAMA, Shusuke, OGAWA, Takaya
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The objects of the present invention are to provide a process for producing crystals of compound (I) easily in an industrial scale, and a stable lyophilized composition of compound (I). It has been found that subjecting an aqueous solution containing compound (I) and an inorganic salt such as sodium chloride to lyophilization yields a lyophilized composition having good storage stability wherein the compound (I) is crystalline, and further that crystals of compound (I) can be obtained from said aqueous solution without lyophilization.