NOVEL OXAZOLE COMPOUNDS AS -CATENIN MODULATORS AND USES THEREOF

NOVEL OXAZOLE COMPOUNDS AS -CATENIN MODULATORS AND USES THEREOF

are provided as inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of β-cat. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way...

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Bibliographische Detailangaben
Hauptverfasser: RAJULU, Gavara, Govinda, DASGUPTA, Ramanuj, DICKSON, John, K
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:are provided as inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of β-cat. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and other conditions related to Wnt pathway dysfunction, including pulmonary fibrosis.