ANTIGEN COMPOSITION FOR DETECTING CHAGAS DISEASE

The present invention concerns a composition of polypeptides suitable for detecting antibodies against Trypanosoma cruzi (T. cruzi ) in an isolated biological sample comprising polypeptides 1F8, JL7 and at least one of the polypeptides selected from the group consisting of Cruzipain, KMP-11 and PAR2...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	ROESSLER, Dieter, MUENCH, Peter, UPMEIER, Barbara, SCHOLZ, Christian, ZARNT, Toralf
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
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Beschreibung
Zusammenfassung:	The present invention concerns a composition of polypeptides suitable for detecting antibodies against Trypanosoma cruzi (T. cruzi ) in an isolated biological sample comprising polypeptides 1F8, JL7 and at least one of the polypeptides selected from the group consisting of Cruzipain, KMP-11 and PAR2. A method of producing a soluble and immunoreactive composition of polypeptides suitable for detecting antibodies against T . cruzi using said composition of polypeptides is also part of the invention. Moreover, the invention concerns a method for detecting antibodies specific for T. cruzi in an isolated sample wherein a composition of said T. cruzi polypeptides is used as well as a reagent kit comprising said composition of T. cruzi polypeptides.