KNOCK-OUT MOUSE, METHOD OF SCREENING MATERIAL SUPPRESSING MESIAL TEMPORAL LOBE EPILEPSY, AND METHOD OF SELECTING TECHNIQUE FOR SUPPRESSING MESIAL TEMPORAL LOBE EPILEPSY

Provided are a knock-out mouse, a method of screening a material suppressing mesial temporal lobe epilepsy, and a method of selecting a technique for suppressing mesial temporal lobe epilepsy. This knock-out mouse is a mouse, which is 30 days old or more, has lost the function of the Gridin gene at...

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Bibliographische Detailangaben
Hauptverfasser:	UCHIYAMA Kozo, ASAI Masato, ENOMOTO Atsushi, TAKAHASHI Masahide, ASAI Naoya
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPIRITS TESTING TRAPPING VINEGAR WINE
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Zusammenfassung:	Provided are a knock-out mouse, a method of screening a material suppressing mesial temporal lobe epilepsy, and a method of selecting a technique for suppressing mesial temporal lobe epilepsy. This knock-out mouse is a mouse, which is 30 days old or more, has lost the function of the Gridin gene at least in the nervous tissue, and also exhibits the phenotypes of (1), (2) and (3) below. (1) Hippocampal sclerosis should be exhibited. (2) Brain damage other than hippocampus should be limited. (3) Auto epilepsy which may be derived from hippocampus should be exhibited.