COMPOSITIONS AND METHODS FOR SILENCING HEPATITIS B VIRUS GENE EXPRESSION

The present invention provides compositions comprising therapeutic nucleic acids such as siRNA that target Hepatitis B virus (HBV) gene expression, lipid particles comprising one or more (e.g., a combination) of the therapeutic nucleic acids, and methods of delivering and/or administering the lipid...

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Bibliographische Detailangaben
Hauptverfasser: DHILLON, Ammen P, LEE, Amy C.H, THI, Emily P, MACLACHLAN, Ian, CROSS, Jennifer L, SNEAD, Nicholas M
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present invention provides compositions comprising therapeutic nucleic acids such as siRNA that target Hepatitis B virus (HBV) gene expression, lipid particles comprising one or more (e.g., a combination) of the therapeutic nucleic acids, and methods of delivering and/or administering the lipid particles (e.g., for treating HBV infection and/or HDV infection in humans).