FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES

A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nocice...

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Hauptverfasser:	SELBY, Matthew Duncan, ZHU, Zhaoning, KEYAERTS, Jean, SHAW, Michael Alan, SWINNEN, Dominique Louis Léon, QUINCEY, Joanna Rachel, HUTCHINGS, Martin Clive, DELIGNY, Michael, EVRARD, Yves, JOHNSON, James Andrew, FORICHER, Yann, DE HARO GARCIA, Teresa, SCHIO, Laurent, FILOCHE-ROMME, Bruno, BROOKINGS, Daniel Christopher, MAC COSS, Malcolm, CALMIANO, Mark Daniel, JADOT, Sophie, XUAN, Mengyang, HEER, Jag Paul
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6, 7-dihydro-7, 14-methanobenzimidazo[1, 2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.