MUTANTS OF LEECH DERIVED NEUTROPHIL ELASTASE INHIBITORS AND USES THEREOF

MUTANTS OF LEECH DERIVED NEUTROPHIL ELASTASE INHIBITORS AND USES THEREOF

The invention relates to a mutant of an antistasin type serine proteinase (NE) inhibitor wherein said mutant is mutated with respect to the wild-type sequence at the amino acid residue immediately following the sixth cysteine residue. Such an antistasin type serine proteinase (NE) inhibitor is prefe...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: VOERMAN, Friso Martijn, VOERMAN, Gerard
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to a mutant of an antistasin type serine proteinase (NE) inhibitor wherein said mutant is mutated with respect to the wild-type sequence at the amino acid residue immediately following the sixth cysteine residue. Such an antistasin type serine proteinase (NE) inhibitor is preferably selected from fahsin, guamerin, piguamerin, hirustasin and bdellastasin and mutant homologs.