DEVICE AND METHODS FOR PRINTING BIOLOGICAL TISSUES AND ORGANS

The invention relates to medicine and biology, particularly to the means for artificial manufacturing of biological tissues and organs, and can be used in biotechnology, bioengineering, tissue engineering, regenerative medicine, and in the 3D-printing of biological tissues and organs. Technical character of the invention consists in the development of a method of printing living tissues and organs as well as of the apparatus for its implementation. The proposed apparatus consists of at least: - a printing platform, - a bioink printing module with at least one nozzle designed for bioink dosing, - a gel-forming composition printing module, containing a UV-module, and at least one nozzle capable of dosing gel-forming composition that starts polymerizing under the influence of UV radiation, - a module for relatively displacing the nozzles and/or the platform, and in which the bioink printing module is separated from the gel-forming-composition printing module in such a way so as to prevent UV radiation from reaching the bioink printing module, the radiation from the UV module being directed predominantly parallel to the platform for printing, in such a way so as to prevent UV radiation from reaching the biological tissues and/or organs being printed. The technical result of the invention is the development of a multi-functional device capable of combining various printing modes, providing a method of high-resolution printing of living tissues and organs based on UV-induced hydrogel polymerization, and a method of cell protection from UV radiation during the printing process.