AMPHIPHILIC BLOCKCOPOLYMERS COMPRISING REDUCTION SENSITIVE BIODEGRADABLE POLYESTERAMIDES

The present invention relates to amphiphilic block copolymers comprising reduction sensitive biodegradable polyesteramides. The present invention also relates to micelles comprising the amphiphilic block copolymers. The invention also relates to drug delivery systems comprising the micelles. The amp...

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Bibliographische Detailangaben
Hauptverfasser:	WANG, Wei, FEIJEN, Jan, SUN, Huanli, MENG, Fenghua, ZHONG, Zhiyuan, DIAS, Aylvin Jorge Angelo Athanasius
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY COMPOSITIONS BASED THEREON HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	The present invention relates to amphiphilic block copolymers comprising reduction sensitive biodegradable polyesteramides. The present invention also relates to micelles comprising the amphiphilic block copolymers. The invention also relates to drug delivery systems comprising the micelles. The amphiphilic block copolymers comprise hydrophilic and hydrophobic blocks whereby the hydrophobic blocks comprise a biodegradable polyesteramide based on alpha-amino acids, diols, aliphatic dicarboxylic acids and optionally diamines whereby at least one of the dicarboxylic acids, diols or diamines comprises disulphide linkages.