METHOD OF PREPARING DABIGATRAN ETEXILATE INTERMEDIATE AND INTERMEDIATE COMPOUND

Disclosed are a method for preparing a dabigatran etexilate intermediate, and an intermediate compound. The method for preparing a dabigatran etexilate intermediate 4 comprises: reacting a compound 3 with a C 1 -C 3 alkyl alcohol solution of methylamine in an organic solvent, wherein, X = chlorine,...

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Bibliographische Detailangaben
Hauptverfasser:	YU, Xiong, GUO, Meng, HU, Mingtong, ZHU, Xueyan, WANG, Duzheng, GUO, Yajun, SHAN, Hanbin, YUAN, Zhedong
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	Disclosed are a method for preparing a dabigatran etexilate intermediate, and an intermediate compound. The method for preparing a dabigatran etexilate intermediate 4 comprises: reacting a compound 3 with a C 1 -C 3 alkyl alcohol solution of methylamine in an organic solvent, wherein, X = chlorine, bromine, or iodine. Also disclosed are an intermediate compound 3 and a preparation method thereof. The method for preparing a dabigatran etexilate intermediate of the present invention has the advantages of simple process, easy operation, high yield, and easy purification, thus being suitable for industrial production.