IRE-1A INHIBITORS

The present invention relates to compounds which directly inhibit IRE-1± activity, and which are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.

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Bibliographische Detailangaben
Hauptverfasser:	LONERGAN, David Gregory, FLYNN, Gary A, ZENG, Qingping, PALLAI, Peter V, PATTERSON, John Bruce
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds which directly inhibit IRE-1± activity, and which are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.