COMBINATIONS OF A PHOTOSENSITIZER WITH A HYDROGEN SULFIDE DONOR, THIOREDOXIN INHIBITOR OR NITROXIDE FOR USE IN PHOTODYNAMIC THERAPY

COMBINATIONS OF A PHOTOSENSITIZER WITH A HYDROGEN SULFIDE DONOR, THIOREDOXIN INHIBITOR OR NITROXIDE FOR USE IN PHOTODYNAMIC THERAPY

Compounds for use The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant syst...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CURNOW, Alison, WHITEMAN, Matthew, PERRY, Alexis, WINYARD, Paul Graham, WOOD, Mark Elliott, FERGUSON, Daniel Colin Jeremy
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Compounds for use The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy.