PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF A PDE10 INHIBITOR

PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF A PDE10 INHIBITOR

The present invention is directed to an improved process for the preparation of compounds of Formula (II) and Formula (III), which are useful in the inhibition of PDE10. In particular, the present invention is directed to an improved process for the preparation of 1-(5-(4-chloro-3,5-dimethoxyphenyl)...

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Bibliographische Detailangaben
Hauptverfasser: MCDERMOTT, Michael James, CUTSHALL, Neil S, LITTLE, Thomas L, BROT, Elisabeth C.A, LUKE, Wayne Douglas, GAGE, Jennifer Lynn, REINEKE, Karl E, JONAS, Marco
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention is directed to an improved process for the preparation of compounds of Formula (II) and Formula (III), which are useful in the inhibition of PDE10. In particular, the present invention is directed to an improved process for the preparation of 1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)ethanone, which is useful in the inhibition of PDE10.