AN IMPROVED PROCESS FOR THE PREPARATION OF AGOMELATINE POLYMORPHIC FORM-1

The invention provides a process for preparation of polymorphic form I of Agomelatine comprising dissolving Agomelatine in a water miscible organic solvent to obtain Agomelatine solution (solution A), preparing a solution of water miscible organic solvent and water (solution B) and cooling to below...

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Bibliographische Detailangaben
Hauptverfasser:	PULLAGURLA, Manik Reddy, NANDAKUMAR, Mecheril Valsan, PITTA, Bhaskar Reddy, RANGISETTY, Jagadeesh Babu
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The invention provides a process for preparation of polymorphic form I of Agomelatine comprising dissolving Agomelatine in a water miscible organic solvent to obtain Agomelatine solution (solution A), preparing a solution of water miscible organic solvent and water (solution B) and cooling to below 0 ºC, adding solution A to solution B at below 0 ºC and precipitating Agomelatine polymorphic Form 1.