HIV PROTEASE INHIBITORS

HIV PROTEASE INHIBITORS

The present invention is directed to 2,6-morpholine derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein Z1, Z2, V1, V2, V3, R6, R6A, and X are defined herein. The invention also relates to methods of using the 2,6-morpholine derivatives of the invention for the inhibit...

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Hauptverfasser: SIVALENKA, Vijayasaradhi, BENNETT, David Jonathan, LESSARD, Stephanie, WILLIAMS, Peter, D, MCCAULEY, John, A, BEAULIEU, Christian, MOLINARO, Carmela, GRESHOCK, Thomas, J, MORADEI, Oscar Miguel, TRUONG, Vouy Linh, BUNGARD, Christopher, J, TUMMANAPALLI, Satyanarayana, HOLLOWAY, M. Katharine, MCKAY, Daniel, CRANE, Sheldon
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention is directed to 2,6-morpholine derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein Z1, Z2, V1, V2, V3, R6, R6A, and X are defined herein. The invention also relates to methods of using the 2,6-morpholine derivatives of the invention for the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.