NOVEL ASSAY TO DETECT HUMAN PERIOSTIN

NOVEL ASSAY TO DETECT HUMAN PERIOSTIN

This disclosure provides a robust, sensitive, and specific assay for the detection and measurement of periostin levels in samples obtained from human patients having, or suspected of having an IL-13-mediated disease or disorder. The disclosure further provides novel antiperiostin monoclonal antibodi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: JEANBLANC, Nicolette, STREICHER, Katie, YAO, Yihong, LEE, Yen-Wah, LIANG, Meina, GREENLEES, Lydia, DILLE, Bruce, PARKER, Melissa, CHOWDHURY, Partha, RANADE, Koustubh, GRANT, Ethan, DAVIS, Gerard, VARKEY, Reena, BROPHY, Susan
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:This disclosure provides a robust, sensitive, and specific assay for the detection and measurement of periostin levels in samples obtained from human patients having, or suspected of having an IL-13-mediated disease or disorder. The disclosure further provides novel antiperiostin monoclonal antibodies that recognize at least isoforms 1, 2, 3, 4, 7, and 8 of human periostin, and assay kits comprising one or more of these antibodies.