TABLET FORMULATION FOR CGRP-ACTIVE COMPOUNDS

TABLET FORMULATION FOR CGRP-ACTIVE COMPOUNDS

The present invention is directed to compositions comprising an extrudate or solid solution of a compound, or a salt thereof, of Formula I (API):wherein "Ra" is independently -H or -F, in a water-soluble polymer matrix which further comprises a disintegration system allowing a tablet made...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PATEL, Paresh, B, XU, Wei, ALLAIN, Leonardo Resende, BROWN, Chad, D, LUPTON, Lisa, IKEDA, Craig, B, NOFSINGER, Rebecca, EICKHOFF, W. Mark, FLANAGAN, Francis, J., Jr, XI, Hanmi, MAROTA, Melanie, JOHNSON, Mary Ann
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention is directed to compositions comprising an extrudate or solid solution of a compound, or a salt thereof, of Formula I (API):wherein "Ra" is independently -H or -F, in a water-soluble polymer matrix which further comprises a disintegration system allowing a tablet made therefrom to rapidly disintegrate in the environment in which the API is to be released.