CRYSTALLINE FORMS OF 2-(TERT-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE

CRYSTALLINE FORMS OF 2-(TERT-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE

The invention provides a method of preparing compound of formula (iv),by contacting the compound of formula (iii) with R1NH2 in the presence of a base or a Lewis acid, in a solvent as defined herewith. The invention further provides a compound of formula (iii),and tautomers thereof, wherein R2 is su...

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Bibliographische Detailangaben
Hauptverfasser: BOERSEN, Nathan Andrew, BEAUCHAMPS, Marie Georges, NAGY, Mark A, HILGRAF, Robert, MUSLEHIDDINOGLU, Jale, YONG, Kelvin Hin-yeong, KOTHARE, Mohit Atul, HUANG, Lianfeng, ZOU, Daozhong, LI, Ying, FERRETTI, Antonio Christian, MAN, Hon-Wah, XU, Jean, ZOU, Nanfei
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention provides a method of preparing compound of formula (iv),by contacting the compound of formula (iii) with R1NH2 in the presence of a base or a Lewis acid, in a solvent as defined herewith. The invention further provides a compound of formula (iii),and tautomers thereof, wherein R2 is substituted or unsubstituted C1-8 alkyl, or substituted saturated cycloalkyl as defined herein.