REDUCING PROTEIN A LEACHING DURING PROTEIN A AFFINITY CHROMATOGRAPHY

REDUCING PROTEIN A LEACHING DURING PROTEIN A AFFINITY CHROMATOGRAPHY

A method for reducing leaching of protein A during protein A affinity chromatography is described which involves reducing temperature of pH of, or by adding one or more protease inhibitors to, a composition that is subject to protein A affinity chromatography.

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Bibliographische Detailangaben
Hauptverfasser: MCDONALD, PAUL J, O'LEARY, RHONA M, LAVERDIERE, AMY, FAHRNER, ROBERT L
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:A method for reducing leaching of protein A during protein A affinity chromatography is described which involves reducing temperature of pH of, or by adding one or more protease inhibitors to, a composition that is subject to protein A affinity chromatography.