IMPROVED FINGOLIMOD PROCESS

IMPROVED FINGOLIMOD PROCESS

The present invention relates to a novel synthetic route for the preparation of fingolimod and its pharmaceutically acceptable salts. The synthetic strategy comprises reaction of 2-(4- octylphenyl)-acetaldehyde with nitro acetonide, and subsequent conversions of the resulting acetonide protected nit...

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Bibliographische Detailangaben
Hauptverfasser: CHAUGULE, Balaji Vasant, BORHADE, Ajit Sahebrao, MEHTA, Samit Satish, GURJAR, Mukund Keshav, PRAMANIK, Chinmoy Mriganka, TRIPATHY, Narendra Kumar, NEELAKANDAN, Kaliyaperumal, KARHADE, Ganesh Kaluram, PATOLE, Jayendra Dattatraya
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to a novel synthetic route for the preparation of fingolimod and its pharmaceutically acceptable salts. The synthetic strategy comprises reaction of 2-(4- octylphenyl)-acetaldehyde with nitro acetonide, and subsequent conversions of the resulting acetonide protected nitro-alcohpl intermediates of formulae (8), (9) and (10) to the penultimate acetonide protected amino intermediates of formula (11), which on deprotection with acid yields Fingolimod and its corresponding salts, having purity conforming to regulatory specification.