PROCESS FOR PRODUCING ACYL AMINO ACIDS EMPLOYING LIPASES

There is provided a microbial cell for producing at least one acyl amino acid, wherein the cell is genetically modified to comprise: - a first genetic mutation that increases the expression relative to a wild type cell of at least one lipase (EC 3.1.1) (E 1 ) capable of hydrolysing at least one glyc...

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Bibliographische Detailangaben
Hauptverfasser:	DECKER, NICOLE, GRAMMANN, KATRIN, HENNEMANN, HANS-GEORG, KIRCHNER, NICOLE, REINECKE, LIV
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	There is provided a microbial cell for producing at least one acyl amino acid, wherein the cell is genetically modified to comprise: - a first genetic mutation that increases the expression relative to a wild type cell of at least one lipase (EC 3.1.1) (E 1 ) capable of hydrolysing at least one glyceride to at least one fatty acid; and - a second and a third genetic mutation that increases the expression relative to a wild type cell of: (i) an amino acid-N-acyl-transferase (EC 2.3.2) (E 2 ), and (ii) an acyl-CoA synthetase (EC 6.2.1.1) (E 3 ) respectively that enables the cell to convert the fatty acid to at least one acyl amino acid and wherein the cell has a reduced fatty acid degradation capacity.