STABILIZED ALPHA-GALACTOSIDASE AND USES THEREOF

The present invention relates to a process of preparing a multimeric protein structure comprising at least two ±-galactosidase monomers being covalently linked to one another via a linking moiety, wherein said linking moiety is not present in native ±-galactosidase, the process comprising reacting ±...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SHEKHTER, Talia, SHAALTIEL, Yoseph, AZULAY, Yaniv, RUDERFER, Ilya, KIZHNER, Tali, SHULMAN, Avidor, BEN-MOSHE, Tehila
Format: Patent
Sprache:eng ; fre ; ger
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Beschreibung
Zusammenfassung:The present invention relates to a process of preparing a multimeric protein structure comprising at least two ±-galactosidase monomers being covalently linked to one another via a linking moiety, wherein said linking moiety is not present in native ±-galactosidase, the process comprising reacting ±-galactosidase with a cross-linking agent which comprises said linking moiety and at least two reactive groups.