LEPTIN mRNA COMPOSITIONS AND FORMULATIONS

LEPTIN mRNA COMPOSITIONS AND FORMULATIONS

A formulation comprising a modified synthetic messenger RNA and a delivery agent. The modified synthetic messenger RNA encodes a leptin protein, is non-replicating and is translation-ready. The formulation can be delivered to a subject with congenital leptin deficiency, lipodystrophy or other condit...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SPLAWSKI, IGOR, ZECRI, FRÉDÉRIC, CAPLAN, SHARI LYNN, HAHM, SEUNG, HELDWEIN, KURT ALEX, GAMBER, GABRIEL GRANT, BYERS, CRYSTAL, ZABAWA, THOMAS
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:A formulation comprising a modified synthetic messenger RNA and a delivery agent. The modified synthetic messenger RNA encodes a leptin protein, is non-replicating and is translation-ready. The formulation can be delivered to a subject with congenital leptin deficiency, lipodystrophy or other condition where circulating leptin level is low.