IMIDAZOTRIAZINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY

A series of substituted imidazo[l,2-b][l,2,4]triazine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerati...

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Hauptverfasser:	QUINCEY, JOANNA RACHEL, JACKSON, VICTORIA ELIZABETH, BROWN, JULIEN ALISTAIR, PORTER, JOHN ROBERT, BROOKINGS, DANIEL CHRISTOPHER
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:	A series of substituted imidazo[l,2-b][l,2,4]triazine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.