FUSED TRICYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY
A series of fused tricyclic imidazole derivatives, in particular dihydro-1H-cyclopenta[4,5]imidazo[1,2-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including aut...
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| creator | CHOVATIA, Praful Tulshi WEHNER, Volkmar ZHU, Zhaoning HEER, Jag, Paul DELIGNY, Michael KROEPLIEN, Boris BRACE, Gareth Neil SWINNEN, Dominique, Louis, Léon BROWN, Julien Alistair QUINCEY, Joanna, Rachel SABNIS, Yogesh, Anil JACKSON, Victoria Elizabeth HEINELT, Uwe GALLIMORE, Ellen Olivia MAC COSS, Malcolm CALMIANO, Mark Daniel ALEXANDER, Rikki Peter |
| description | A series of fused tricyclic imidazole derivatives, in particular dihydro-1H-cyclopenta[4,5]imidazo[1,2-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. |
| format | Patent |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | FUSED TRICYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY |
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