FUSED TRICYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY

A series of fused tricyclic imidazole derivatives, in particular dihydro-1H-cyclopenta[4,5]imidazo[1,2-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including aut...

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Hauptverfasser:	CHOVATIA, Praful Tulshi, WEHNER, Volkmar, ZHU, Zhaoning, HEER, Jag, Paul, DELIGNY, Michael, KROEPLIEN, Boris, BRACE, Gareth Neil, SWINNEN, Dominique, Louis, Léon, BROWN, Julien Alistair, QUINCEY, Joanna, Rachel, SABNIS, Yogesh, Anil, JACKSON, Victoria Elizabeth, HEINELT, Uwe, GALLIMORE, Ellen Olivia, MAC COSS, Malcolm, CALMIANO, Mark Daniel, ALEXANDER, Rikki Peter
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:	A series of fused tricyclic imidazole derivatives, in particular dihydro-1H-cyclopenta[4,5]imidazo[1,2-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.