COMPOUNDS AND COMPOSITIONS FOR IMAGING GCC-EXPRESSING CELLS

COMPOUNDS AND COMPOSITIONS FOR IMAGING GCC-EXPRESSING CELLS

This disclosure provides radiolabeled compounds that bind to guanylyl cyclase C (GCC) and which can bind cancer cells that express GCC. Exemplary compounds comprise a chelating moiety capable of binding a radioactive atom, a peptide capable of binding GCC, and a linker moiety connecting the two. Thi...

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Bibliographische Detailangaben
Hauptverfasser: DANIELS, TAMARA, ANDERSON, CVET, DONNA, SCHULTZ, MICHAEL, K, HOPPIN, JOHN, WILLIAM, RAUT, SWAPNIL, NORENBERG, JEFFREY, P
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:This disclosure provides radiolabeled compounds that bind to guanylyl cyclase C (GCC) and which can bind cancer cells that express GCC. Exemplary compounds comprise a chelating moiety capable of binding a radioactive atom, a peptide capable of binding GCC, and a linker moiety connecting the two. This disclosure also provides methods of detecting and treating cancer using the compounds described herein.