5,6,7,8-TETRAHYDRO-5,8-METHANOCINNOLINE DERIVATIVES AS RORC MODULATORS FOR THE TREATMENT OF AUTOIMMUNE DISEASES

Compounds of the formula I: or a pharmaceutical salt thereof, wherein X, Ar1, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

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Bibliographische Detailangaben
Hauptverfasser: KILLEN, Jonathan, BODIL VAN NIEL, Monique, GOBBI, Alberto, HURLEY, Christopher, WARD, Stuart, FAUBER, Benjamin, HURST, David, CRIDLAND, Andrew, MAXEY, Robert
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Compounds of the formula I: or a pharmaceutical salt thereof, wherein X, Ar1, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.