HEMOGLOBIN A1c MEASUREMENT METHOD AND MEASUREMENT KIT

This invention provides an amadoriase that acts on the ²-chain of hemoglobin A1c (HbA1c) and generates hydrogen peroxide, a method for measurement of HbA1c using such amadoriase, and a reagent kit for measurement of HbAlc using such amadoriase. The method for measurement of HbAlc involves the use of...

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Bibliographische Detailangaben
Hauptverfasser:	ICHIYANAGI Atsushi, MASAKARI Yosuke
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	This invention provides an amadoriase that acts on the ²-chain of hemoglobin A1c (HbA1c) and generates hydrogen peroxide, a method for measurement of HbA1c using such amadoriase, and a reagent kit for measurement of HbAlc using such amadoriase. The method for measurement of HbAlc involves the use of an amadoriase that has specific activity of 0.1 U/mg or greater to ±F6P and oxidizes the HbA1c ²-chain amino terminus so as to generate hydrogen peroxide, and the reagent kit for measurement of HbA1c comprises such amadoriase. The method and the kit for measurement of HbAlc enable quantification of HbAlc to be performed rapidly, simply, and accurately.