MODIFIED AGRIN-FRAGMENT CAPABLE OF RESTORING MUSCLE STRENGTH FOR USE AS A MEDICAMENT

MODIFIED AGRIN-FRAGMENT CAPABLE OF RESTORING MUSCLE STRENGTH FOR USE AS A MEDICAMENT

Modified agrin fragment having in vivo activity, comprising at least the domains LG2 and LG3 of human or mouse agrin in covalently interlinked form and modified in such a way that the fragment cannot be cleaved by neurotrypsin for use in the treatment of neuromuscular diseases or diseases of nerve,...

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Hauptverfasser: VRIJBLOED, Jan Willem, HETTWER, Stefan, KUCSERA, Stefan
Format: Patent
Sprache:eng ; fre ; ger
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CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator VRIJBLOED, Jan Willem
HETTWER, Stefan
KUCSERA, Stefan
description Modified agrin fragment having in vivo activity, comprising at least the domains LG2 and LG3 of human or mouse agrin in covalently interlinked form and modified in such a way that the fragment cannot be cleaved by neurotrypsin for use in the treatment of neuromuscular diseases or diseases of nerve, muscle and neuromuscular junctions, wherein the modified agrin fragment is characterized in that its ²-cleavage site is deleted or modified.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title MODIFIED AGRIN-FRAGMENT CAPABLE OF RESTORING MUSCLE STRENGTH FOR USE AS A MEDICAMENT
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