MODIFIED AGRIN-FRAGMENT CAPABLE OF RESTORING MUSCLE STRENGTH FOR USE AS A MEDICAMENT

MODIFIED AGRIN-FRAGMENT CAPABLE OF RESTORING MUSCLE STRENGTH FOR USE AS A MEDICAMENT

Modified agrin fragment having in vivo activity, comprising at least the domains LG2 and LG3 of human or mouse agrin in covalently interlinked form and modified in such a way that the fragment cannot be cleaved by neurotrypsin for use in the treatment of neuromuscular diseases or diseases of nerve,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: VRIJBLOED, Jan Willem, HETTWER, Stefan, KUCSERA, Stefan
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Modified agrin fragment having in vivo activity, comprising at least the domains LG2 and LG3 of human or mouse agrin in covalently interlinked form and modified in such a way that the fragment cannot be cleaved by neurotrypsin for use in the treatment of neuromuscular diseases or diseases of nerve, muscle and neuromuscular junctions, wherein the modified agrin fragment is characterized in that its ²-cleavage site is deleted or modified.