PREPARATION OF RADIOIODINATED 3-FLUOROPROPYL-NOR-BETA-CIT

PREPARATION OF RADIOIODINATED 3-FLUOROPROPYL-NOR-BETA-CIT

The invention generally provides processes for the preparation of radioiodinated 3-fluoropropyl-nor- -CIT. In particular, the process uses an arylsilane intermediate, thus avoiding the use of hexamethylditin, and reducing the number of steps previously required for the preparation of radioiodinated...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser: HUDSON, Edmund C
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention generally provides processes for the preparation of radioiodinated 3-fluoropropyl-nor- -CIT. In particular, the process uses an arylsilane intermediate, thus avoiding the use of hexamethylditin, and reducing the number of steps previously required for the preparation of radioiodinated 3-fluoropropyl-nor- -CIT from anhydroecgonine methyl ester. The invention also relates to the alkylation of a nortropane to the corresponding N-(3-fluoropropyl) analog using 3-fluoropropanal.