ANTIBODIES WITH MODIFIED ISOELECTRIC POINTS

ANTIBODIES WITH MODIFIED ISOELECTRIC POINTS

The invention relates generally to compositions and methods for altering the isoelectric point of an antibody, and in some cases, resulting in improved plasma pharmacokinetics, e.g. increased serum half-life in vivo.

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Bibliographische Detailangaben
Hauptverfasser: LAZAR, Gregory, A, DAHIYAT, Bassil, I, BERNETT, Matthew, J
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The invention relates generally to compositions and methods for altering the isoelectric point of an antibody, and in some cases, resulting in improved plasma pharmacokinetics, e.g. increased serum half-life in vivo.