METHODS FOR PRODUCING SIALYLATED THERAPEUTIC PROTEINS

The present invention relates to a transformed mammalian cell comprising a heterologous nucleic acid sequence (i) encoding a polypeptide comprising the catalytic domain of ST6Gal1 and, optionally, at least one nucleic acid sequence (ii) encoding a therapeutic protein comprising at least one glycosyl...

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Bibliographische Detailangaben
1. Verfasser:	RONIN, Catherine
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a transformed mammalian cell comprising a heterologous nucleic acid sequence (i) encoding a polypeptide comprising the catalytic domain of ST6Gal1 and, optionally, at least one nucleic acid sequence (ii) encoding a therapeutic protein comprising at least one glycosylation site, said transformed mammalian cell expressing the therapeutic protein with a sialylation on said at least one glycosylation site.