LIQUID FORMULATION COMPRISING ADALIMUMAB AND AN ACETATE BUFFER

LIQUID FORMULATION COMPRISING ADALIMUMAB AND AN ACETATE BUFFER

The present invention provides antigen binding proteins which bind specifically to TNF-alpha. For example novel variants of anti-TNF antibodies such as adalimumab which show increased binding to the FcRn receptor or increased half life compared to adalimumab. Also provided are compositions comprisin...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: YASIN, AHMED, MOLLOY, MICHAEL J, TOMLINSON, IAN M, ELLIS, JONATHAN HENRY, SHAH, TEJASH
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The present invention provides antigen binding proteins which bind specifically to TNF-alpha. For example novel variants of anti-TNF antibodies such as adalimumab which show increased binding to the FcRn receptor or increased half life compared to adalimumab. Also provided are compositions comprising the antigen binding proteins and uses of such compositions in treatment of disorders and disease.