PROCESS FOR PREPARING AMPHIPHILIC PEPTIDE DERIVATIVES

The present invention relates to novel derivatives of hydrophilic bioactive peptides which have been modified by introducing a lipophilic substituent through esterification of the free carboxylic group(s) of the peptide with an aliphatic alcohol. The present invention also refers to a simple, fast a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	BRAGA, JANAÍNA FÉLIX, OLIVEIRA, MARIANA FLÁVIA DE, SANTOS, ROBSON AUGUSTO SOUZA DOS, SOUSA NETO, DIÓGENES, FREZARD, FREDERIC JEAN GEORGES
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to novel derivatives of hydrophilic bioactive peptides which have been modified by introducing a lipophilic substituent through esterification of the free carboxylic group(s) of the peptide with an aliphatic alcohol. The present invention also refers to a simple, fast and effective process for the preparation of amphiphilic derivatives of peptides. It also refers to pharmaceutical compositions for the controlled release and delivery of these pharmacologically active peptides.