BICYCLIC SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS

The present invention provides compounds of Formula I, and pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav1.7. The compounds are useful for the treatment of diseases associated with the activity of sodium channels such as pain disord...

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Bibliographische Detailangaben
Hauptverfasser:	MARX, Isaac E, HUANG, Hongbin, CHU-MOYER, Margaret Yuhua, BOEZIO, Christiane, BUTLER, John R, MILGRAM, Benjamin Charles, WEISS, Matthew, NGUYEN, Hanh Nho, ROMERO, Karina Vaida, BOEZIO, Alessandro, PETERSON, Emily, DINEEN, Thomas, LA, Daniel, SPARLING, Brian, KREIMAN, Charles, DIMAURO, Erin F, GRACEFFA, Russell, GUZMAN-PEREZ, Angel
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides compounds of Formula I, and pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav1.7. The compounds are useful for the treatment of diseases associated with the activity of sodium channels such as pain disorders and itch. Also provided are pharmaceutical compositions containing compounds of the present invention.