METHOD FOR PRODUCING BETA-HEMATIN CRYSTAL COMPRISING STEP OF HEATING

This invention provides a method of preparing a ²-hematin crystal comprising a step of heating, the ²-hematin crystal obtained by such method, and a vaccine adjuvant composition containing the ²-hematin crystal. The ²-hematin crystal has a needle-like morphology, it has an average particle size of 0...

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Hauptverfasser:	ISHII, Ken, KANO, Yasumasa, OTSUKI, Akina, COBAN, Cevayir, AKIRA, Shizuo, IGARI, Yoshikatsu
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Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	ISHII, Ken KANO, Yasumasa OTSUKI, Akina COBAN, Cevayir AKIRA, Shizuo IGARI, Yoshikatsu
description	This invention provides a method of preparing a ²-hematin crystal comprising a step of heating, the ²-hematin crystal obtained by such method, and a vaccine adjuvant composition containing the ²-hematin crystal. The ²-hematin crystal has a needle-like morphology, it has an average particle size of 0.6 to 1.2 µm, and it exhibits main peaks characteristics for angles of diffraction (2¸) of 7.4°, 12.2°, 21.6°, and 24.1° in an X-ray diffraction pattern obtained by powder X-ray diffractometry with Cu-K± rays (with each peak including a plus-minus 0.2° diffraction angle).
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The ²-hematin crystal has a needle-like morphology, it has an average particle size of 0.6 to 1.2 µm, and it exhibits main peaks characteristics for angles of diffraction (2¸) of 7.4°, 12.2°, 21.6°, and 24.1° in an X-ray diffraction pattern obtained by powder X-ray diffractometry with Cu-K± rays (with each peak including a plus-minus 0.2° diffraction angle).</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180711&DB=EPODOC&CC=EP&NR=3006446B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180711&DB=EPODOC&CC=EP&NR=3006446B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ISHII, Ken</creatorcontrib><creatorcontrib>KANO, Yasumasa</creatorcontrib><creatorcontrib>OTSUKI, Akina</creatorcontrib><creatorcontrib>COBAN, Cevayir</creatorcontrib><creatorcontrib>AKIRA, Shizuo</creatorcontrib><creatorcontrib>IGARI, Yoshikatsu</creatorcontrib><title>METHOD FOR PRODUCING BETA-HEMATIN CRYSTAL COMPRISING STEP OF HEATING</title><description>This invention provides a method of preparing a ²-hematin crystal comprising a step of heating, the ²-hematin crystal obtained by such method, and a vaccine adjuvant composition containing the ²-hematin crystal. 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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	METHOD FOR PRODUCING BETA-HEMATIN CRYSTAL COMPRISING STEP OF HEATING
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