METHOD FOR PRODUCING BETA-HEMATIN CRYSTAL COMPRISING STEP OF HEATING

This invention provides a method of preparing a ²-hematin crystal comprising a step of heating, the ²-hematin crystal obtained by such method, and a vaccine adjuvant composition containing the ²-hematin crystal. The ²-hematin crystal has a needle-like morphology, it has an average particle size of 0...

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Bibliographische Detailangaben
Hauptverfasser:	ISHII, Ken, KANO, Yasumasa, OTSUKI, Akina, COBAN, Cevayir, AKIRA, Shizuo, IGARI, Yoshikatsu
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention provides a method of preparing a ²-hematin crystal comprising a step of heating, the ²-hematin crystal obtained by such method, and a vaccine adjuvant composition containing the ²-hematin crystal. The ²-hematin crystal has a needle-like morphology, it has an average particle size of 0.6 to 1.2 µm, and it exhibits main peaks characteristics for angles of diffraction (2¸) of 7.4°, 12.2°, 21.6°, and 24.1° in an X-ray diffraction pattern obtained by powder X-ray diffractometry with Cu-K± rays (with each peak including a plus-minus 0.2° diffraction angle).